The FZR (1C7) Monoclonal Antibody from Bioss Inc. is a Mouse Monoclonal antibody to FZR1. This antibody recognizes Human antigen. The FZR (1C7) Monoclonal Antibody has been validated for the following applications: Immunofluorescence, and Western Blot.
Description
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis